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Steroid derivatives of purine‐6(1 H )‐thione (1a‐c)
Author(s) -
Carroll F. I.,
Philip Abraham,
Ferguson Anna M.,
Wall Monroe F.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050612
Subject(s) - chemistry , alkylation , purine , steroid , purine metabolism , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , enzyme , hormone , catalysis
The products obtained as a result of the alkylation of purine‐6(1 H )‐thione, and 6‐alkylthiopurines with steroidal‐21‐( p ‐bromobenzenesullonates) (H) and 3‐methoxy‐16α‐bromoestra‐1,3,5 (10)‐tricne‐17‐one (IV) is reported. The ratio of 9‐alkylated to 7‐alkylated purine in the alkylation of 6‐methylthiopurine (VI) is presented. The use of the S ‐diphenylmethylprotecling group in the syntheses of sensitive 9‐steroidal‐9 H ‐purine‐6(1 H )‐thiones is discussed.