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NMR proof of the structure of 4‐aminoquinolines and pyridines
Author(s) -
Craig John C.,
Pearson D. E.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050508
Subject(s) - chemistry , aminoquinolines , alkyl , aminopyridines , nmr spectra database , hydrogen , nuclear magnetic resonance spectroscopy , hydrogen bond , proton nmr , stereochemistry , medicinal chemistry , organic chemistry , molecule , combinatorial chemistry , spectral line , physics , astronomy
Nmr spectra of a number of 4‐ N ‐alkylaminoquinolines and 4‐ N ‐alkylaminopyridines show coupling between hydrogen of the amino group and α‐hydrogen on the alkyl group. No such coupling would be observed if the hydrogen were on heterocyclic nitrogen. Other nmr characteristics in the benzenoid region suggest that all simple 4‐aminoquinolines and 4‐aminopyridines have the amino structure.