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Synthetic Amebicides. VIII. 7,7′‐[Iminobis(alkyleneimino) [bis[benz[ c ] acridines] and Congeneric 9‐Aminoacridines, 12‐Aminobenz[ a ] acridines, [2‐Aminobenz[ b ] acridines, and 4‐Aminoquinolines
Author(s) -
Elslager Edward F.,
Short Franklin W.,
Tendick Frank H.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050503
Subject(s) - chemistry , medicinal chemistry , acridine derivatives , stereochemistry
Thirty‐five 7,7′‐(iminodialkylenediimino))bis[benz[ c ]acridines] (VII), 7,7′‐(alkylene‐ and phenylenediimino)bis[benz[ c ]acridines] (VIII and IXa‐c), [iminobis(alkyleneimino)]bis[acridines, benz[ a ]acridines, benz[ b ]acridines, and quinolines] (X, Xla‐c, XII, XIII, and XIVa‐c), and [alkylenebis(iminoalkyleneimino)]bis[acridines, benz[ c ]acridines, and quinolincs] (XVI, XVII, XVIIIa and b, and XIXa‐c) were synthesized by the condensation of one equivalent of the appropriate alkylenediamine with two equivalents of the requisite chloroheterocycle in phenol. Many of the bis(aminoheterocyclic) compounds are highly active against Entamoeba histolytica in vitro and in experimental animals.