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Reissert compound studies. XVII. Phosphorus‐containing reissert compound analogues
Author(s) -
Spatz David M.,
Popp Frank D.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050409
Subject(s) - chemistry , isoquinoline , alkylation , hydrolysis , potassium , base (topology) , phosphorus , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , mathematical analysis , mathematics
The reaction of isoquinoline, potassium cyamide, and chlorophosphates or chlorothiophosphates leads to the formation of phosphorus containing analogues of Reisert compounds. These analogues can be converted by base to an anion which undergoes elimination to isoquinaldonitrile or which can be alkylated. Acid‐catalysed hydrolysis of the analogues leads to isoquinoline.