Aromaticity in heterocyclic systems V. Bromination studies of certain purines, pyrrolo[3,2‐ d ]pyrimidines and pyrazolo[4,3‐ d ]pyrimidines | Zendy

Cassidy Frederick | Zendy; Olsen Richard K. | Zendy; Robins Roland K. | Zendy

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Aromaticity in heterocyclic systems V. Bromination studies of certain purines, pyrrolo[3,2‐ d ]pyrimidines and pyrazolo[4,3‐ d ]pyrimidines

Author(s) -

Cassidy Frederick,

Olsen Richard K.,

Robins Roland K.

Publication year - 1968

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570050404

Subject(s) - chemistry , halogenation , bromine , purine metabolism , reactivity (psychology) , xanthine , bicyclic molecule , stereochemistry , aromaticity , medicinal chemistry , organic chemistry , molecule , pathology , medicine , alternative medicine , enzyme

The bromination of certain selected purines, pyrrolo[3,2‐d]pyrimidines and pyrazolo[4,3‐ d ]‐pyrimidines has been studied and the reactivity of these systems compared. Displacement of a carboxyl group by bromine was noted in the case of 6‐carboxypyrrolo[3,2‐ d ]‐2,4‐pyrimidinedione. In contrast to xanthine, 2,6‐diethoxypurine readily brominated at position 8. Pyrazolo‐[4,3‐ d ]‐7‐pyrimidone was readily brominated at position 3.

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