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Friedel crafts reactions of three‐member ileterocycles II: Alkylation of aromatic compounds with aziridines
Author(s) -
Milstein Norman
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050307
Subject(s) - chemistry , friedel–crafts reaction , chlorobenzene , toluene , substituent , phenethylamine , aziridine , alkylation , benzene , medicinal chemistry , chloride , organic chemistry , catalysis , ring (chemistry) , stereochemistry
Abstract The Friedel Crafts reaction of propylenimine with symmetrical arenes in the presence of aluminum chloride was investigated. Electron donating substituents increase the α‐methyl‐β‐phenethylamine/ β‐methyl‐β‐phenethylaimine ratio, while increasing the temperature has the opposite effect. In the reaction of chlorobenzene or toluene with aziridine, the nature of the substituent has little effect on the ortho/para ratio.