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Thiazolo‐ N ‐hydroxyuracils
Author(s) -
Bauer Ludwig,
Mahajanshetti C. S.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050305
Subject(s) - chemistry , hydroxamic acid , solvent , organic chemistry , medicinal chemistry , stereochemistry
The partial Lossen degradation of the hydroxamic acid group at C‐4 or C‐5 of sodium 4,5‐thiazoledicarbohydroxamate (IIIb) and its 2‐methyl analog (IIIe) initiated a multicoursed reaction which furnished a mixture of thiazolo[4,5‐ d ]‐ and thiazolo[5,4‐ d ]‐ N ‐hydroxyuracils. The isomer distribution was sensitive to the solvent systems in which these reactions were carried out. The structure of the isomers so obtained was established by chemical and spectral methods.