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Synthesis of some 6‐methoxyimidazo[1,2‐b]pyridazines
Author(s) -
Lombardino Joseph G.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050106
Subject(s) - chemistry , pyridazine , ring (chemistry) , condensation , medicinal chemistry , mannich reaction , organic chemistry , stereochemistry , catalysis , physics , thermodynamics
Abstract The synthesis of 6‐methoxyimidazo[1,2‐ b ]pyridazine and its 2‐methyl analog is reported. Carboxylic acids, esters and quaternary salts derived from this ring system are described and the heterocyclic system is shown to undergo the Mannich reaction. A condensation reaction of the 2‐methyl group is reported and nuclear magnetic resonance (nmr) spectra and acidity constants of some imidazo[1,2‐ b ]pyridazines are recorded.