Pyrimidines. XXI. 1‐(Tetrahydro‐2‐furyl)pyrimidines | Zendy

Noell C. Wayne | Zendy; Cheng C. C. | Zendy

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Pyrimidines. XXI. 1‐(Tetrahydro‐2‐furyl)pyrimidines

Author(s) -

Noell C. Wayne,

Cheng C. C.

Publication year - 1968

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570050104

Subject(s) - chemistry , cytosine , pyrimidine , combinatorial chemistry , uracil , stereochemistry , dna , biochemistry

A number of 1‐(tetrahydro‐2‐furyl)uracils, cytosines and related compounds were synthesized by a modified Hilbert‐Johnson method from 2‐chlorotetrahydrofuran and the corresponding 2,4‐dimethoxypyrimidines. The relative stability in acid of tetrahydrofuryl and tetrahydropyranyl moieties in compounds of this type was discussed. 2‐Oxo‐4‐methoxy‐1,2‐dihydropyrimidine, a compound which has been erroneously reported, has now been prepared and its structure confirmed by conversion into cytosine.

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