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Some hydroxylated derivatives of chlorpromazine
Author(s) -
Grotta H. M.,
Page T. F.,
Riggle C. J.,
Manian A. A.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040425
Subject(s) - chemistry , chlorpromazine , derivative (finance) , phenothiazine , stereochemistry , combinatorial chemistry , pharmacology , medicine , financial economics , economics
As part of a program to determine the metabolic fate of chlorpromazine [2‐chloro‐10‐(3‐dimethylaminopropyl)phenothiazine] (I), the synthesis of several hydroxylated derivatives of I was undertaken. This paper reports the preparation and structural verification of the 1‐ and 6‐hydroxy and the desdimethyl 3‐hydroxy derivative, and summarizes unsuccessful attempts to prepare the 4‐hydroxy derivative of I.