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A new synthesis of thiazolo[3,2‐ a ] pyrimidinones
Author(s) -
Andrew H. F.,
Bradsher C. K.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040419
Subject(s) - chemistry , pyrimidinones , alkylation , thiouracil , sulfuric acid , medicinal chemistry , organic chemistry , medicine , catalysis , thyroid
Abstract 5 H ‐Thiazolo[3,2‐ a ]pyrimidin‐5‐ones (V) have been prepared by S ‐alkylation of 6‐methyl‐2‐thiouracil (Ib) with bromoacetone or bromoacetophenone followed by cyclization in sulfuric acid. By the same series of reactions, 2‐thiouracil (Ia) gave rise to 7 H ‐thiazolo[3,2‐ a ]pyrimidin‐7‐ones (VI). The properties and structures of the intermediates and products are discussed.