Premium
A new synthesis of thiazolo[3,2‐ a ] pyrimidinones
Author(s) -
Andrew H. F.,
Bradsher C. K.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040419
Subject(s) - chemistry , pyrimidinones , alkylation , thiouracil , sulfuric acid , medicinal chemistry , organic chemistry , medicine , catalysis , thyroid
5 H ‐Thiazolo[3,2‐ a ]pyrimidin‐5‐ones (V) have been prepared by S ‐alkylation of 6‐methyl‐2‐thiouracil (Ib) with bromoacetone or bromoacetophenone followed by cyclization in sulfuric acid. By the same series of reactions, 2‐thiouracil (Ia) gave rise to 7 H ‐thiazolo[3,2‐ a ]pyrimidin‐7‐ones (VI). The properties and structures of the intermediates and products are discussed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom