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1,4‐disubstituted pyridazino[4,5‐ d ] pyridazines
Author(s) -
Dorman Linneaus C.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040406
Subject(s) - chemistry , pyridazine , steric effects , nucleophilic substitution , nucleophile , medicinal chemistry , stereochemistry , organic chemistry , catalysis
1,4‐Bis(methyIthio)pyridazino[4,5‐ d ]pyridazine (IV) was synthesized from 4,5‐pyridazinedi‐carboxylic acid in three steps. By employing IV as an intermediate, various 1,4‐disubstituted pyridazino[4,5‐ d ]pyridazine derivatives of classes 1,4‐ N ,S; 1,4‐ N ,O; 1,4‐ O,S ; and 1,4‐ O,O were prepared by one‐step or two‐step nucleophilic substitution reactions. Steric, polar and resonance effects were observed in some of these reactions and are discussed.