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Synthesis and properties of trimethylsilyl derivatives of vitamin B 6
Author(s) -
Sennello Lawrence T.,
Kummerow F. A.,
Argoudelis C. J.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040223
Subject(s) - pyridoxamine , chemistry , pyridoxal , vitamin , vitamin b , trimethylsilyl , yeast , biochemistry , biosynthesis , pyridoxine , yeast extract , stereochemistry , organic chemistry , vitamin b6 , fermentation , phosphate , enzyme
In our studies on the biosynthesis of vitamin B 6 in yeast (2), we are confronted with the problem of a fairly rapid assay of the different forms (known and unknown) of this nutrient that are excreted into the culture medium. The existing assay procedures for vitamin B 6 are subject to at least one of several restrictions. They are time consuming, incapable of distinguishing between the three forms of the vitamin (pyridoxol, pyridoxal, and pyridoxamine), or preclude the regeneration and reisolation of the material after analysis.