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Synthesis of possible metabolites of menazon
Author(s) -
Stevens M. A.,
Walker G. H.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040218
Subject(s) - chemistry , peracetic acid , metabolite , triazine , oxide , organic chemistry , stereochemistry , biochemistry , hydrogen peroxide
A product of the peracetic acid oxidation of 2,4‐diamino‐6‐methylthiomethyl‐1,3,5‐triazine is identical with a major urinary metabolite of the aphicide, menazon, in the rat. This product has been shown to be the S ‐oxide 2,4‐diamino‐6‐methylsulphinyl‐methyl‐1, 3, 5‐triazine and not the N ‐oxide.
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