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Synthesis of certain tricyclic quinoline derivatives as potential antiamebal agents
Author(s) -
Can Joseph G.,
Lazaris Spyros A.,
Wunderlich Thomas A.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040216
Subject(s) - chemistry , quinoline , tricyclic , substituent , ring (chemistry) , alkaloid , stereochemistry , benzene , organic chemistry
Synthesis of the fused tricyclic systems, 1, 2, 3, 3a, 4, 5‐hexahydropyrrolo[1, 2a]quinoline (I) and 2, 3, 4, 4a, 5, 6‐hexahydro 1 H ‐benzo[ c ]quinolizine (II), each bearing an ethoxyl substituent on the benzene ring, has been achieved. The compounds combine certain structural features of the alkaloid emetine and of 8‐quinolinols.