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Synthesis of 6‐hydroxymethyl‐1,3‐dimethyllumazine by rearrangement of the corresponding 6‐methyllumazine 5‐oxide
Author(s) -
Zondler Helmut,
Forrest H. S.,
Lagowski J. M.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040122
Subject(s) - chemistry , hydroxymethyl , oxide , product (mathematics) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , geometry , mathematics
Starting with a chloronitrouracil, the synthesis of 1, 3, 6‐trimethyllumazine has been achieved. Oxidation to the 5‐oxide and subsequent rearrangement gave 6‐hydroxymethyl‐1, 3‐dimethyllumazine. Because of the method of synthesis, the product is uncontaminated with the 7‐isomer.