Premium
The chemistry of pyrazine and its derivatives. XII. The reaction of acetonylpyrazine with phenyllithium in the presence and absence of methyl benzoate
Author(s) -
Chakrabartty Sujit K.,
Levine Robert
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040119
Subject(s) - phenyllithium , chemistry , pyrazine , medicinal chemistry , methyl benzoate , organic chemistry , stereochemistry
The reaction of acetonylpyrazine with phenyllithium in the absence and presence of methyl benzoate gives (a) 2‐phenyl‐6‐acetonylpyrazine (IV) and (b) a mixture of IV and 3‐(2‐phenyl‐6‐pyrazyl)‐4‐phenylbutane‐2, 4‐dione (V, VI), respectively. Evidence in support of the structures of the products has been presented and comments on their formation are made.