Premium Irreversible enzyme inhibitors. LXXXV. On the mode of pyrimidine binding of 5‐alkyl and 5‐arylpyrimidines to dihydrofolic reductasePremium
Baker B. R.,
Lourens Gerhardus J.,
Jordaan Johannes H.
journal of heterocyclic chemistry
Abstract A series of 5‐isoamyl‐ and 5‐( p ‐chlorophenyl)pyrimidines substituted with amino, alkylamino, mercapto, benzyloxy, hydroxy, or hydrogen at the 2‐ and 4‐positions and with amino or methyl at the 6‐position have been synthesized for evaluation of the mode of pyrimidine binding to dihydrofolic reductase. The studies were performed in order to determine where a bulky group could be placed on the pyrimidine ring that would still allow good binding; such studies are essential to find a suitable position for placement of a covalent forming group for design of active‐site‐directed irreversible inhibitors. Two classes of candidate compounds have emerged for further study as irreversible inhibitors, namely, 2‐amino‐4‐mercapto‐6‐( p ‐bromoacetamidophenylalkyl)‐pyrimidines and 2,4‐diamino‐6‐( p ‐bromoacetamidophenylalkyl)aminopyrimidines having a group such as phenyl, phenylbutyl or isoamyl at the 5‐position that can give strong hydrophobic bonding to the enzyme.
Subject(s)biochemistry , chemistry , covalent bond , enzyme , hydrogen bond , molecule , organic chemistry , pyrimidine , reductase , ring (chemistry) , stereochemistry
SCImago Journal Rank0.321
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