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Synthesis of some N ‐methylated pteridines related to 7,8‐dihydroxanthopterin
Author(s) -
Zondler Helmut,
Forrest H. S.,
Lagowski J. M.
Publication year - 1967
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570040103
Subject(s) - chemistry , ring (chemistry) , uracil , closure (psychology) , derivative (finance) , nitro , condensation , stereochemistry , medicinal chemistry , organic chemistry , dna , biochemistry , alkyl , physics , economics , financial economics , market economy , thermodynamics
Seven methylated pteridines have been synthesized by condensation of a 4‐chloro‐5‐nitropyrimidine with a β‐ketoamine (or a blocked derivative), reduction of the nitro group, and subsequent ring closure. This scheme provides a new route to dihydroxanthopterin. Several cases are reported, however, in the uracil series where ring closure could not be effected.