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Stereochemical studies on 7‐substituted 8‐oxa‐1‐azabicyclo[4.3.0]nonanes
Author(s) -
Crabb T. A.,
Newton R. F.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030405
Subject(s) - geminal , chemistry , methylene , coupling constant , computational chemistry , stereochemistry , infrared , medicinal chemistry , quantum mechanics , physics
A set of racemic 7‐substituted 8‐oxa‐1‐azabicyclo[4.3.0]nonanes have been prepared and configurational and conformational assignments made on the basis of the value of the geminal coupling constants for the C 9 methylene protons. The limitations of the Bohlmann infrared criterion in studying the conformations of these compounds is discussed.