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New reactions of pyrroles. I. pyridylethylpyrroles
Author(s) -
Archibald John L.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030403
Subject(s) - chemistry , pyrrole , pyridine , catalysis , group (periodic table) , medicinal chemistry , displacement (psychology) , organic chemistry , psychology , psychotherapist
Pyrroles with unsubstituted 2‐ and/or 5‐positions are found to react with 4‐vinyl‐pyridine, giving hitherto unreported 2‐ and 2,5‐di‐ pyridylethylpyrroles. Pyrrole‐2‐carboxylic acids can also react to give the same products by displacement of the carboxyl group. Pyridylethylation at an available 3‐ and/or 4‐position was not observed. Catalytic reductions and alkylations of the resulting piperidylethylpyrroles are also reported.