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Synthesis of 1,3,4‐thiadiazoles containing the trifluoromethyl group
Author(s) -
Lalezari I.,
Sharghi N.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030320
Subject(s) - sulfanilamide , chemistry , trifluoromethyl , thiadiazoles , stereochemistry , in vitro , medicinal chemistry , antifungal , organic chemistry , biochemistry , microbiology and biotechnology , alkyl , biology
The following compounds have been synthesized: 2‐Amino‐5‐trifluoromethyl‐1,3,4‐thiadiazole; N ‐(5‐trifluoromethyl ‐ 1,3,4‐thiadizol‐2‐yl)benzenesulfonamide; N 1 ‐(5‐trifluoromethyl‐1,3,4‐thiadiazol‐2‐yl)sulfanilamide, its N 4 ‐acetyl, N 4 ‐succinyl, and N 4 ‐pathalyl derivatives; o ‐ m ‐ and p ‐trifluoromethylbenzoylthiosemicarbazide, their corresponding 2‐amino‐1,3,4‐thiadiazoles, their corresponding sulfanilamides, their N 4 ‐acetyl, N 4 ‐succinyl and N 4 ‐phthalyl derivatives; 3‐ o ‐trifluoromethylphenyl‐4 H ‐1,2,4‐triazole‐5‐thiol. Preliminary in‐vitro assays show that synthesized sulfanilamide derivatives have antibacterial activity against Staphylococcus aureus.