Premium
The synthesis of substituted 8‐quinolinols
Author(s) -
Kolobielski Marjan
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030308
Subject(s) - chemistry , alkylation , isopropyl , demethylation , hydrochloride , isopropyl alcohol , ether , organic chemistry , ethylene , medicinal chemistry , catalysis , biochemistry , gene expression , dna methylation , gene
2‐Isopropyl‐8‐quinolinol was prepared by alkylation of 8‐methoxyquinoline followed by demethylation. The 7‐isopropyl‐8‐quinolinol was prepared in three steps from o ‐isopropylphenol. The reaction of 5‐chloromethyl‐8‐quinolinol hydrochloride with alcohols, amines, ethylene glycols and ether‐alcohols gave the corresponding 5‐substituted derivatives of 8‐quinolinol.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom