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Novel methylation. III . Methylation of tertiary amines such as pyridine and isoquinoline with alkyl carboxylates
Author(s) -
Kametani Tetsuji,
Kigasawa Kazuo,
Hayasaka Tetsutaro,
Hiiragi Mineharu,
Ishimaru Haruhide,
Asagi Setsu
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030204
Subject(s) - chemistry , isoquinoline , alkyl , methylation , alkylation , triethylamine , pyridine , ammonium , organic chemistry , medicinal chemistry , biochemistry , catalysis , gene
The alkylation of tertiary amines, namely, 2‐dimethylaminoethanol, triethylamine, pyridine and isoquinoline with various alkyl carboxylates was investigated. This reaction afforded the corresponding quarternary ammonium salts, e.g. , methylation of 2‐dimethyl‐aminoethanol with methyl salicylate.
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