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A convenient preparation of indoline
Author(s) -
Dolby Lloyd J.,
Gribble Gordon W.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030202
Subject(s) - indoline , chemistry , indole test , phosphoric acid , zinc , polymerization , organic chemistry , combinatorial chemistry , polymer
An efficient method for chemically reducing indole to indoline using zinc dust and 85% phosphoric acid is described. 2, 3‐Dimethylindole, 1,2,3, 4‐tetrahydrocarbazole and N ‐methyl‐l,2,3,4‐tetrahydrocarbazole are also reduced to the corresponding dihydroindoles in somewhat lower yields. Unlike earlier acid‐metal reductions of indole little or no polymerization is observed.