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Synthesis of alkylaminoethanethiolsulfuric acids substituted with heterocyclic moieties
Author(s) -
Singerman Gary M.,
Kimura Ryuichi,
Riebsomer J. L.,
Castle Raymond N.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030116
Subject(s) - chemistry , stereochemistry , medicinal chemistry
Several alkylaminoethanethiolsulfurie acids substituted with heterocyclic moieties have been synthesized to determine their effectiveness as radiation protection agents. These compounds are represented by the structure R(CH 2 ) 3 NH(CH 2 ) 2 S 2 O 3 H, where R is 8‐quinoly‐oxy (V), 8‐quinaldyloxy (IX), 5‐quinolyloxy (XII), 4‐pyridyl (XVI), and 4‐pyridylmethyl (XXIII). The diheterocyclic‐substituted compound, 2‐[bis‐(2‐phenyl‐1, 2, 3, 2 H ‐triazol‐4‐ylmethyl)amino]ethanethiolsulfuric acid (XIV) was also synthesized.
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