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The action of organolithium compounds on phthalazine and I (2H)‐phthalazinone
Author(s) -
Hisrch A.,
Orphanos D. G.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030108
Subject(s) - phthalazine , chemistry , hydrolysis , organolithium compounds , medicinal chemistry , organic chemistry , ion , deprotonation
Phthalazine and 1(2H)‐phthalazinone undergo 1,2‐addition of organolithium compounds to C = N to give, following hydrolysis, 1 ‐ substituted ‐ 1,2 ‐ dihydrophthalazines and 4‐substituted‐3,4‐dihydro‐1(2H)‐phthalazinones respectively. These dihydro‐derivatives may be easily autoxidized to the corresponding 1‐substituted phthalazines and 4‐substituted‐1(2H)‐phthalazinones.