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Thiazolo [3,2‐a] pyridinium salts
Author(s) -
Bradsher C. K.,
Lohr D. F.
Publication year - 1966
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570030106
Subject(s) - chemistry , pyridinium , nitration , pyridine , perchlorate , ring (chemistry) , yield (engineering) , medicinal chemistry , pyridinium compounds , nitro , organic chemistry , ion , materials science , alkyl , metallurgy
The sulfides formed by the reaction of α‐halo ketones or α‐halo acetals with 2‐mercaptopyridine may be cyclized in good yield to form thiazolo[3, 2‐a]pyridinium salts. The presence of chloro or nitro substituents on the pyridine ring does not interfere with the synthesis. Nitration of 3‐methylthiazolo[3, 2‐a]pyridinium perchlorate has been found to occur at position 8.
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