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Cinnoline chemistry. XII. The synthesis of 6‐fluoro‐4‐methylcinnoline and other cinnolines as potential antitumor agents
Author(s) -
Castle Raymond N.,
Adachi Kikuo,
Guither William D.
Publication year - 1965
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570020426
Subject(s) - cinnoline , chemistry , combinatorial chemistry , organic chemistry , oxide , medicinal chemistry
6‐Fluoro‐4‐methylcinnoline (IX) has been synthesized in eight steps from 4‐fluoroaniline. A series of styryl and pyridylethenyl cinnolines have been prepared from 6‐fluoro‐4‐methylcinnoline (IX), 4‐methylcinnoline and 4‐methylcinnoline‐2‐oxide. Furthermore, a series of 4‐substituted benzylthiocinnolines have been prepared.