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Morphanthridines I. 11‐aminoalkylidene‐and ll‐(4‐Piperidylene)‐5,6‐dihydromorphanthridines
Author(s) -
Drukker Alexander E.,
Judd Claude I.,
Spoerl Joan M.,
Kaminski Frank E.
Publication year - 1965
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570020311
Subject(s) - chemistry , reagent , dehydration , grignard reagent , grignard reaction , organic chemistry , combinatorial chemistry , biochemistry
New methods are described for the preparation of 5,6‐dihydro‐11‐morphanthridone, 5‐substituted 5,6‐dihydro‐11‐morphanthridones and nuclear halogenated derivatives. Basic Grignard reagents convert these ketones to carbinols, which through dehydration affords a convenient route to straight chain and cyclic 11‐aminoalkylidene derivatives.
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