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The alkylation of 6‐aryl‐6,7‐diazaspiro [3.4]octane‐5,8‐diones
Author(s) -
Brabander Herbert J.,
Wright William B.
Publication year - 1965
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570020204
Subject(s) - chemistry , octane , alkylation , aryl , organic chemistry , medicinal chemistry , alkyl , catalysis
The synthesis of 8‐ tert ‐aminoalkoxy‐6‐aryl‐6,7‐diazaspiro[3.4]oct‐7‐en‐5‐ones (1) and 6‐ tert ‐aminoalkyl‐7‐aryl‐6,7‐diazaspiro[3.4]octane‐5,8‐diones has been accomplished. Two synthetic methods are described, each of which yields principally one isomer or the other.