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Pyridazines. II. The synthesis of amino‐, azido‐ and nitraminopyridazines, tetrazolo[1,5‐b] pyridazines and related nitrogen heterocycles
Author(s) -
Guither William D.,
Clark Donald G.,
Castle Raymond N.
Publication year - 1965
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570020112
Subject(s) - chemistry , pyridazine , pyrimidine , nitrogen , chemical transformation , stereochemistry , transformation (genetics) , medicinal chemistry , organic chemistry , biochemistry , gene
The remaining three diaminopyridazines, 3, 4, 5‐triaminopyridazine and several nitraminopyridazines have been prepared. The structure of 3,4, 5‐triaminopyridazine and the 3, 5‐diamino‐4‐nitropyridazine precursor have been established by n.in.r. analysis. In addition 8‐amino‐6‐chloro‐, 8‐amino‐6‐hydrazino‐ and 8‐amino‐6‐azidotetrazolo‐[1, 5‐b]pyridazine has been synthesized along with 4, 6‐dihydrazino‐ and 4, 6‐diazido‐pyrimidine. Several other chemical transformation of these compounds are described.