Premium
Pyrimidines. XIV. Synthesis of 1‐substituted 5,6‐dihydrocytosines and an improved synthesis of 1‐substituted uracils
Author(s) -
Cheng C. C.,
Lewis Leland R.
Publication year - 1964
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570010512
Subject(s) - chemistry , acrylonitrile , medicinal chemistry , organic chemistry , polymer , copolymer
1‐Substituted 5, 6‐dihydrouracils (VI) and 1‐substituted 5, 6‐dihydrocytosines (V) were prepared by cyclization of N‐substituted N‐β‐cyanoethyl ureas (IV) in acid and basic medium, respectively. Compounds N were synthesized from cyanic acid and β‐(substituted amino)propionitriles (III), the latter in turn were prepared from primary amines (I) and acrylonitrile (II). Preparations of 1‐substituted uracils (VII) from VI were carried out by known procedures.