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Imidazo[4,5‐d]pyridazines. III. The Synthesis of 2‐phenylimidazo [4,5‐d]‐pyridazines
Author(s) -
Malm Miriam,
Castle Raymond N.
Publication year - 1964
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570010406
Subject(s) - chemistry , pyridazine , medicinal chemistry , stereochemistry
Based upon an analogy with “Dyrenium”, (6‐phenyl‐2,4,7‐triaminopteridine) (I), 4,7‐diamino‐2‐phenylimidazo[4, 5‐d]pyridazine (II) has been prepared. This compound has been found to possess diuretic activity. In addition a number of other substituted 2‐phenylimidazo[4, 5‐d]pyridazines have been prepared.