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Synthetic routes to β, β‐diaryl‐α‐amino acids via nitrogen hetercycles
Author(s) -
Filler Robert,
Rao Y. Shyamsunder
Publication year - 1964
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570010311
Subject(s) - chemistry , oxazolone , piperazine , ring (chemistry) , cleavage (geology) , amino acid , organic chemistry , stereochemistry , combinatorial chemistry , biochemistry , geotechnical engineering , fracture (geology) , engineering
β, β‐Diphenylalanine and its ring‐substituted analogs are prepared from oxazolones, thiazolones, imidazolones, hydantoins, thiohydantoins, and piperazine 2,5‐diones by alkaline ring opening followed by acid cleavage of the N‐benzoyl group. The oxazolone approach, with its variations, offers the most advantageous route to these compounds. Several new amino acids are described.