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NaBH 4 ‐I 2 mediated chemoselective reduction of γ‐lactam and thio‐γ‐lactam in presence of gem‐dicarboxylates: An easy access to 1,3‐diaryl pyrrolidines
Author(s) -
Barman Gopa,
Haldar Pranab,
Dutta Neelanjan,
Ray Jayanta K.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.542
Subject(s) - chemistry , lactam , thio , aryl , pyrrolidine , chemoselectivity , yield (engineering) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl , materials science , metallurgy
Substituted pyrrolidine derivatives were synthesized in high yield by NaBH 4 /I 2 mediated chemoselective reduction of N ‐aryl‐γ‐lactam and N ‐aryl‐thio‐γ‐lactam‐2,2‐dicarboxylate. With excess NaBH 4 /I 2 , carbonyl functionality of the ester groups remained unchanged. J. Heterocyclic Chem., (2011).