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Synthesis of novel 2‐(2‐methylsulfonyl‐1‐methyl‐1 H ‐imidazol‐5‐yl)‐5‐(alkylsulfonyl)‐1,3,4‐thiadiazoles
Author(s) -
Javidnia Azita,
Akbarzadeh Tahmineh,
Firoozpour Loghman,
Khoobi Mehdi,
Shafiee Abbas,
Foroumadi Alireza
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.535
Subject(s) - chemistry , thiadiazoles , imidazole , hydroxymethyl , medicinal chemistry , stereochemistry , antimicrobial , nuclear magnetic resonance spectroscopy , organic chemistry
Abstract Starting from 5‐hydroxymethyl‐2‐mercapto‐1‐methyl‐1 H ‐imidazole (1), a series of 2‐(1‐methyl‐2‐methylsulfonyl‐1 H ‐imidazol‐5‐yl)‐5‐alkylthio and 5‐alkylsulfonyl‐1,3,4‐thiadiazole derivatives ( 9a , 9b , 9c , 9d and 10a , 10b , 10c , 10d ) were prepared as potential antimicrobial agents . The structure of the obtained compounds was confirmed by NMR, IR, Mass spectroscopy, and elemental analysis. J. Heterocyclic Chem., (2010)