Premium
Facile synthesis of 4‐alkoxycarbonylisoquinoline‐1,3‐diones and 5‐alkoxycarbonyl‐2‐benzazepine‐1,3‐diones via a mild alkaline cyclization
Author(s) -
Billamboz Muriel,
Bailly Fabrice,
Cotelle Philippe
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.52
Subject(s) - benzazepine , chemistry , organic chemistry , stereochemistry , medicinal chemistry , combinatorial chemistry
A series of 4‐methoxycarbonylisoquinoline‐1,3‐diones was obtained from homophthalic acid in four steps. The key step was the quantitative and rapid alkaline cyclization of 2‐methoxycarbonyl‐2‐(2‐methoxycarbonylphenyl) acetamides. Homologation easily afforded in the same conditions 5‐carboxy‐2‐benzazepine‐1,3‐dione. J. Heterocyclic Chem., 46, 392 (2009).