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Efficient and one‐pot catalytic synthesis of 2‐imidazolines and bis‐imidazolines with p ‐toluenesulfonic acid under solvent free conditions
Author(s) -
NasrEsfahani Masoud,
Montazerozohori Morteza,
Mehrizi Safie
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.516
Subject(s) - chemistry , ethylenediamine , catalysis , p toluenesulfonic acid , pyridinium , imidazoline receptor , organic chemistry , environmentally friendly , combinatorial chemistry , solvent , medicine , ecology , biology
A practical, efficient, and inexpensive method for the synthesis of 2‐imidazoline from the reaction of nitriles with ethylenediamine or 1,2‐propanediamine using p ‐toluenesulfonic acid or pyridinium p ‐toluenesulfonate under reflux conditions is reported. This catalyst can be successfully applied for the chemoselective conversion of dicyanobenzenes to corresponding mono‐ and bis‐imidazolines. The applications of these catalysts are feasible because of easy preparation, easy handling, stability, inexpensive, good activity, and eco‐friendly. J. Heterocyclic Chem., (2011).