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An efficient one‐pot solvent‐free synthesis of 2,3‐dihydroquinazoline‐4(1H)‐ones via Al/Al 2 O 3 nanoparticles
Author(s) -
Kassaee M. Z.,
Rostamizadeh Shahnaz,
Shadjou Nasrin,
Motamedi Elahe,
Esmaeelzadeh Maryam
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.506
Subject(s) - chemistry , catalysis , solvent , nanoparticle , medicinal chemistry , reaction conditions , one pot synthesis , nuclear chemistry , combinatorial chemistry , organic chemistry , nanotechnology , materials science
An efficient one‐pot, solvent‐free method is reported for the synthesis of 2‐phenyl‐2,3‐dihydroquinazoline‐4(1H)‐one as well as its o ‐Cl, o ‐OMe, m ‐Br, m ‐NO 2 , p ‐OH, p ‐NO 2 , p ‐CN, p ‐PhCH 2 O, p ‐Cl, p ‐F, p ‐Br, p ‐Me, and o,m ‐dichloro derivatives, using our “as‐prepared” arc discharge fabricated Al/Al 2 O 3 nanoparticles. Compared with our previous report and other known methods, this route gives higher yields with shorter reaction times, whereas its green catalyst appears recyclable at least four times‐with minor decrease in its catalytic activity , under mild conditions. J. Heterocyclic Chem., (2010).