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Synthesis, characterization, and antimicrobial activity of 3′‐(4‐(2‐substituted thiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones
Author(s) -
Mhaske Pravin C.,
Shelke Shivaji H.,
Jadhav Rahul P.,
Raundal Hemant N.,
Patil Sachin V.,
Patil Amar A.,
Bobade Vivek D.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.503
Subject(s) - chemistry , thiazolidine , indoline , antimicrobial , gram , proton nmr , carbon 13 nmr , elemental analysis , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , bacteria , biology , genetics
A series of 3′‐(4‐(2‐methyl/phenyl/benzylthiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones was synthesized. The structures of the synthesized compounds were evaluated by analytical and spectral (IR, 1 H NMR, 13 C NMR, LC‐MS, and elemental analysis) methods. All the synthesized compounds were screened for qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the derivatives showed good activity towards Gram‐positive and Gram‐negative bacteria. J. Heterocyclic Chem., (2010).