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One‐pot synthesis and antimicrobial activity of novel quinolone heterocyclic derivatives
Author(s) -
Zheng Hui,
Liu Juan,
Zhang Pengfei
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.501
Subject(s) - chemistry , quinolone , bacillus subtilis , antimicrobial , broad spectrum , carbon 13 nmr , combinatorial chemistry , staphylococcus aureus , proton nmr , elemental analysis , mass spectrum , organic chemistry , stereochemistry , antibiotics , bacteria , biochemistry , ion , biology , genetics
A series of novel quinolone heterocyclic derivatives from natural amino acid were synthesized in one‐pot method, which is very beneficial for the industrial operation to save manufacturing costs. These new compounds were characterized by 1 H NMR, 13 C NMR, infrared spectrum, mass spectrum, and elemental analysis. The preliminary bioassays results revealed that they had certain antimicrobial activity against Bacillus subtilis and Staphylococcus aureus . J. Heterocyclic Chem., (2010).