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Synthesis of norcantharidin‐dimer derivatives
Author(s) -
Deng Liping,
Yong Zhang,
Tao Weifeng,
Shen Jianfeng,
Wang Wei
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.483
Subject(s) - chemistry , hydrazone , dimer , oxime , cycloaddition , molecule , ethylene diamine , combinatorial chemistry , diamine , stereochemistry , organic chemistry , catalysis , nuclear chemistry
We use one molecule of ethylene diamine as a connecting arm to combine two molecules of 5,6‐dehydronorcantharidin. Then, ten novel norcantharidin derivatives were synthesized in a single step by the [3 + 2] 1,3‐dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine‐T, which is simpler than the conventional method. J. Heterocyclic Chem., 2011.