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A facile and efficient synthesis of bis(oxazoline)s
Author(s) -
Li Wei Jie,
Qiu Sheng Xiang
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.477
Subject(s) - chemistry , oxazoline , toluene , furan , benzene , thiophene , organic chemistry , dicarboxylic acid , combinatorial chemistry , catalysis
AbstractThiophene‐2,5‐dicarboxylic acid, benzene‐1,3‐dicarboxylic acid, or furan‐2,5‐di‐carboxylic acid, respectively, reacted with various β‐amino alcohols in toluene under reflux within 24 h, to form nine bis(oxazoline)s ( 1 , 1a , 1b , 1c , 1d , 1e , 2 , 2a , 2b , 2c , 3 ) in good yields through water deprivation via a one‐pot reaction. The synthetic method is facile and efficient and deserves great application potentials in the research and development in the area of bis(oxazoline)s. J. Heterocyclic Chem., (2010).