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Synthesis of novel functionalized 4‐aza‐2,3‐didehydropodophyllotoxin derivatives with potential antitumor activity
Author(s) -
Kumar Ajay,
Alegria Antonio E.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.467
Subject(s) - chemistry , ethanol , combinatorial chemistry , organic chemistry
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N ‐(2‐hydroxy‐ethyl)‐2,3‐didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50–70% were obtained. J. Heterocyclic Chem., (2010).
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