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One‐step synthesis of 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid from isoflavones and arginine
Author(s) -
Zhang ZunTing,
Han WenYong,
Qiu Li
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.466
Subject(s) - chemistry , isoflavones , combinatorial chemistry , arginine , organic chemistry , two step , amino acid , stereochemistry , biochemistry
A simple and straightforward methodology toward the synthesis of novel 2‐amino‐5‐(4,5‐diphenylpyrimidin‐2‐ylamino)pentanoic acid has been developed by one‐step reaction of isoflavones with arginine. A series of 14 new compounds was reported. All of them were characterized by FTIR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities making this methodology suitable for library synthesis in drug discovery. J. Heterocyclic Chem., (2010).