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Synthesis and anti‐ Helicobacter pylori activity of 4‐(coumarin‐3‐yl)thiazol‐2‐ylhydrazone derivatives
Author(s) -
Chimenti Franco,
Bizzarri Bruna,
Bolasco Adriana,
Secci Daniela,
Chimenti Paola,
Granese Arianna,
Carradori Simone,
D'Ascenzio Melissa,
Scaltrito M. Maddalena,
Sisto Francesca
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.464
Subject(s) - chemistry , coumarin , thiazole , semicarbazone , conjugated system , helicobacter pylori , metronidazole , antibacterial activity , stereochemistry , combinatorial chemistry , organic chemistry , bacteria , antibiotics , biochemistry , medicine , biology , genetics , polymer
A novel class of coumarin‐thiazole conjugated systems (1‐31) were synthesized by Hantzsch condensation between α‐bromo‐3‐acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains, including four metronidazole resistant ones. J. Heterocyclic Chem., (2010).