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A simple and efficient synthesis of some novel thiazolidine‐4‐one derivatives
Author(s) -
Porshamsian Khalil,
Montazeri Naser,
RadMoghadam Kurosh,
AliAsgari Safa
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.458
Subject(s) - chemistry , thiazolidine , dimethyl acetylenedicarboxylate , alkyl , acetylenedicarboxylate , simple (philosophy) , medicinal chemistry , organic chemistry , combinatorial chemistry , cycloaddition , catalysis , philosophy , epistemology
Reaction of 4‐phenylthiosemicarbazide with dialkyl acetylenedicarboxylate in CH 2 Cl 2 at 0°C lead to construction of alkyl 3‐amino‐2‐phenyliminothiazolidine‐4‐one‐5‐ylidene acetate in a few minutes and good yields. Alternatively, the use of thiosemicarbazide has given the corresponding 3‐amino‐2‐iminothiazolidine‐4‐one‐5‐ylidene acetate, while application of di‐ t ‐butylacetylenedicarboxylate in these reactions has not entailed with cyclization. J. Heterocyclic Chem., (2010).