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Toward a novel approach to bis‐β‐lactam synthesis using Vilsmeier reagent as an efficient entity via Staudinger cycloaddition reaction
Author(s) -
Meshram Jyotsna,
Ali Parvez,
Tiwari Vandana
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.455
Subject(s) - chemistry , reagent , ketene , cycloaddition , dimethylformamide , staudinger reaction , imine , combinatorial chemistry , lactam , acetic anhydride , acetic acid , organic chemistry , catalysis , solvent
A facile synthesis of bis‐β‐lactams has been executed using chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N , N ‐dimethylformamide and phosphorus oxychloride. It works out as a versatile acid activator reagent for the direct [2 + 2] ketene–imine cycloaddition of substituted acetic acid and bis‐imines in one‐pot synthesis under mild conditions. Thus, this method has been proved as a high yielding, efficient, and cheap protocol for bis‐β‐lactam synthesis. J. Heterocyclic Chem., (2010).