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Copper‐catalyzed alkyne cycloaddition on electron deficient azides via tetrazolo[1,5‐ a ]pyrimidines
Author(s) -
Nilsson Linda I.,
Ertan Anne,
Weigelt Dirk,
Nolsöe Jens M. J.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.449
Subject(s) - chemistry , cycloaddition , alkyne , catalysis , copper , combinatorial chemistry , organic chemistry
Tetrazolo[1,5‐ a ]pyrimidines are capable of serving as masked azides in copper‐catalyzed Huisgen cyclization with a variety of terminal alkynes, providing a simple protocol for the generation of novel 4′‐substituted 2‐(1′,2′,3′‐triazol‐1′‐yl)pyrimidines. J. Heterocyclic Chem., (2010).